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dc.creatorNikolic, Valentina
dc.creatorStajkovic, Novica
dc.creatorStamenković, Gorana
dc.creatorCekanac, Radovan
dc.creatorMarusic, Predrag
dc.creatorSiljic, Marina
dc.creatorGligic, Ana
dc.creatorStanojevic, Maja
dc.date.accessioned2016-05-23T11:00:47Z
dc.date.issued2014
dc.identifier.issn1567-7257
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/2295
dc.description.abstractTula hantavirus (TULV) belongs to Bunyaviridae family, with negative sense RNA genome. Segmented nature of hantaviral genome allows for genetic reassortment, but the evidence of homologous recombination also exists. In this study we analyzed TULV sequences isolated in Serbia on different occasions and from different rodent hosts: 1987 strain from Microtus subterraneus and 2007 strain from Microtus arvalis. Phylogenetic analysis of both L and S segment sequences is suggestive of geographically related clustering, as previously shown for majority of hantaviruses. Reconstruction of phylogenetic tree for TULV S segment showed that both sequences from Serbia clustered together with sequences from East Slovakia, which had previously been shown to be recombinants (Kosice strain). Exploratory recombination analysis, supported by phylogenetic and amino acid pattern analysis, revealed the presence of recombination in the S segment sequences from Serbia, resulting in mosaic-like structure of TULV S segment similar to the one of Kosice strain. Although recombination is considered a rare event in molecular evolution of negative strand RNA viruses, obtained molecular data in this study support evidence of recombination in TULV, in geographically distant regions of Europe. (C) 2013 Elsevier B.V. All rights reserved.
dc.description.sponsorshipMinistry of Education and Science Republic of Serbia {[}175024]
dc.languageEnglish
dc.rightsrestrictedAccess
dc.sourceInfection Genetics and Evolution
dc.subjectRecombination
dc.subjectTula virus
dc.subjectPhylogenetic analysis
dc.subjectMolecular evolution
dc.titleEvidence of recombination in Tula virus strains from Serbia
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЦеканац, Радован; Стајковиц, Новица; Марусиц, Предраг; Станојевиц, Маја; Стаменковић, Горана; Николиц, Валентина; Глигиц, Aна; Сиљиц, Марина; Евиденце оф рецомбинатион ин Тула вирус страинс фром Сербиа;
dc.citation.volume21
dc.identifier.doi10.1016/j.meegid.2013.08.020
dc.identifier.scopus2-s2.0-84893774623
dc.identifier.wos000332273800056
dc.citation.spage472
dc.citation.epage478
dc.type.versionpublishedVersionen


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