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dc.creatorMilošević, Verica
dc.creatorTodorovic, Danijela
dc.creatorŠošić-Jurjević, Branka
dc.creatorMedigovic, Ivana
dc.creatorPantelic, Jasmina
dc.creatorUscebrka, Gordana
dc.creatorAjdžanović, Vladimir
dc.date.accessioned2016-05-23T11:00:48Z
dc.date.available2016-05-23T11:00:48Z
dc.date.issued2014
dc.identifier.issn1821-4339
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/2302
dc.description.abstractThe effects of estradiol (EDP) and human chorionic gonadotropin (HCG) on histological and stereological features of adrenocorticotropic (ACTH) cells in peripubertal female rats were examined. The first group of females received five injections of EDP (0.25 mg/kg b.w.), every second day from the 4th to 14th day after birth, and was killed at the peripubertal stage. The second group of females was given two injections of pregnyl-gonadotrophinum chorionicum (HCG; 50 IU/kg body weight) on the 36th and 37th days after birth, and it was killed 24 h after the last treatment. The controls were injected with an equivalent volume of the corresponding vehicle. ACTH cells were immunohistochemically labeled and stereologically evaluated. Stereological analysis showed that the volume of ACTH cells and their volume density in peripubertal females treated with EDP, were decreased by 15.6\% and 53.8\% (p < 0.05), respectively, compared to the controls. In HCG-treated animals, the observed parameters were increased by 39.2\% and 15.4\% (p < 0.05), respectively, in comparison with the control females. These findings suggest that the application of EDP or HCG exerted opposite effects on the stereological features of pituitary ACTH cells.
dc.description.sponsorshipMinistry of Education, Science and Technological Development of the Republic of Serbia {[}ON 173009]
dc.languageEnglish
dc.rightsrestrictedAccess
dc.sourceArchives of Biological Sciences
dc.subjectEstradiol
dc.subjecthistology
dc.subjectstereology
dc.titleTHE EFFECTS OF ESTRADIOL AND HUMAN CHORIONIC GONADOTROPIN ON ACTH CELLS IN PERIPUBERTAL FEMALE RATS: A HISTOLOGICAL AND STEREOLOGICAL STUDY
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAјджановић, Владимир; Пантелиц, Јасмина; Тодоровиц, Данијела; Милосевиц, Верица; Медиговиц, Ивана; Усцебрка, Гордана; Шошић-Јурјевић, Бранка Т.;
dc.citation.issue1
dc.citation.volume66
dc.identifier.doi10.2298/ABS1401143M
dc.identifier.scopus2-s2.0-84892395156
dc.identifier.wos000330552400021
dc.citation.spage143
dc.citation.epage148
dc.type.versionpublishedVersionen


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