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dc.creatorBožić, Iva
dc.creatorSavić, Danijela
dc.creatorStevanovic, Ivana
dc.creatorPeković, Sanja
dc.creatorNedeljkovic, Nadezda
dc.creatorLavrnja, Irena
dc.date.accessioned2016-05-23T11:00:58Z
dc.date.issued2015
dc.identifier.issn1662-5102
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/2363
dc.description.abstractChronic microglial activation and resulting sustained neuroinflammatory reaction are generally associated with neurodegeneration. Activated microglia acquires proinflammatory cellular profile that generates oxidative burst. Their persistent activation exacerbates inflammation, which damages healthy neurons via cytotoxic mediators, such as superoxide radical anion and nitric oxide. In our recent study, we have shown that benfotiamine (S-benzoylthiamine 0-monophosphate) possesses anti-inflammatory effects. Here, the effects of benfotiamine on the pro-oxidative component of activity of LPS-stimulated BV -2 cells were investigated. The activation of microglia was accompanied by upregulation of intracellular antioxidative defense, which was further promoted in the presence of benfotiamine. Namely, activated microglia exposed to non-cytotoxic doses of benfotiamine showed increased levels and activities of hydrogen peroxide- and superoxide removing enzymes catalase and glutathione system, and superoxide dismutase. In addition, benfotiamine showed the capacity to directly scavenge superoxide radical anion. As a consequence, benfotiamine suppressed the activation of microglia and provoked a decrease in NO and O-center dot(2)- production and lipid peroxidation. In conclusion, benfotiamine might silence pro-oxidative activity of microglia to alleviate/prevent oxidative damage of neighboring CNS cells.
dc.description.sponsorshipMinistry of Education, Science and Technological Development of the Republic of Serbia {[}III41014]
dc.languageEnglish
dc.rightsrestrictedAccess
dc.sourceFrontiers in Cellular Neuroscience
dc.subjectbenfotiamine
dc.subjectmicroglia
dc.subjectoxidative stress
dc.subjectcatalase
dc.subjectglutathione
dc.titleBenfotiamine upregulates antioxidative system in activated BV-2 microglia cells
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБозиц, Ива; Лаврња, Ирена Ц.; Недељковиц, Надезда; Стевановиц, Ивана; Пековић, Сања; Савиц, Данијела;
dc.citation.issue351
dc.citation.volume9
dc.identifier.doi10.3389/fncel.2015.00351
dc.identifier.scopus2-s2.0-84941005805
dc.identifier.wos000361242600001
dc.type.versionpublishedVersionen
dc.citation.rankM21


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