Spektralna analiza elektrokortikalne aktivnosti mozga pacova u modelu intoksikacije aluminijumom
Spectral analysis of electrocortical brain activity in rat model of aluminium intoxication
Doctoral thesis (Published version)
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The aim of the study was quantitative and qualitative analysis of electrocortical brainactivity in rat model of aluminium intoxication. We used animal model of aluminiumintoxication becouse aluminium toxicity is widespread in nature. Aluminium has selectiveeffects on different brain regiones. Animal model included different variables, so it can beused to study neurotoxicity in different conditiones. Also, processes due to neurotoxicitycan be compared with state of some acute or chronic diseases.Spectral analysis was based on Fast Fourie Transform and changes of electrocorticalactivity was obsreved in relation to frequency ranges. Comparation of power spectra andstatistic analyses was used for quantification of changes in brain activity. We recordedelectrocortical activity of parietal cortex and cerebellum to include all parameters ofintoxication: acumulation in tissue, changes of neuronal local group activity and changes inregulatory function - plasticity and adaptability of brain. Experimental procedure includeddifferent parametars of intoxication - aplication of aluminium, brain structure, doses, age,straint and physiological state of animals. Based on obtained data we define effects ofneurotoxicity. Biological parameters, such as neurotoxical effects, physiological changeand intoxication are matematicaly analyzed. Results suggest that the change of brainactivity can be used in diagnoses and prognoses of pathophisiological state.This study presents synthesis of biological, physiological and medical aspect.
Keywords:Neurotoxicity; Electrophysiology; Spectral analysis
Source:University of Belgrade, Faculty of Biology, 2013, -