Interventions for age-related diseases: Shifting the paradigm
Mladenović Đorđević, Aleksandra
Henriques, Catarina M.
Gonos, Efstathios S.
Trejo, José Luis
Rasmussen, Lene Juel
Article (Published version)
MetadataShow full item record
Over 60% of people aged over 65 are affected by multiple morbidities, which are more difficult to treat, generate increased healthcare costs and lead to poor quality of life compared to individual diseases. With the number of older people steadily increasing this presents a societal challenge. Age is the major risk factor for age-related diseases and recent research developments have led to the proposal that pharmacological interventions targeting common mechanisms of ageing may be able to delay the onset of multimorbidity. Here we review the state of the knowledge of multimorbidity, appraise the available evidence supporting the role of mechanisms of ageing in the development of the most common age-related diseases and assess potential molecules that may successfully target those key mechanisms.
Keywords:Multimorbidity; Ageing; Chronic diseases; Geroprotectors; Geroscience
Source:Mechanisms of Ageing and Development, 2016, 160, 69-92
- Brain plasticity in aging: effect of dietary restriction and anesthesia (RS-173056)
- COST Action (BM1402: MouseAGE)
- Danish National Research Foundation (DNRF115)
- Danish Council for Independent Research (Sapere Aude, DFF-Starting Grant 2014)
- Danish Cancer Society (KBVU-2014)
- Fundação para a Ciência e Tecnologia (FCT, Portugal), SFRH/BPD/76642/2011 and SFRH/BD/86584/2012