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dc.creatorMatić, Miloš M.
dc.creatorMilošević, Marija D.
dc.creatorPaunović, Milica G.
dc.creatorOgnjanović, Branka I.
dc.creatorŠtajn, Andraš Š.
dc.creatorSaičić, Zorica
dc.date.accessioned2017-11-23T11:05:56Z
dc.date.available2017-11-23T11:05:56Z
dc.date.issued2016
dc.identifier.issn1450-9636
dc.identifier.urihttp://www.pmf.kg.ac.rs/KJS/images/volumes/vol38/kjs38maticmilosevic135.pdf
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/2616
dc.description.abstractParacetamol (acetaminophen) is widely used as an ov er-the-counter analgesic and antipyretic drug. The aim of this stu dy was to investigate the possible protective effects of vitamin C (100mg/kg/day i.p.) and β -glucan (40 mg/kg/day i.p.) on altered haematological, biochemical and oxidative s tress parameters in the blood of rats treated with paracetamol (100 mg/kg/day i.p.) for 3 days. Exposure of rats to paracetamol caused changes of some haematological parameters (R BCs count, Hb concentration, Ht value and WBCs count), suggesting that the paraceta mol induced haematotoxicity. Paracetamol reduced serum total protein (TP), album in and globulin, while increased alanine aminotransferase (ALT), aspartate aminotran sferase (AST) and lactate dehydrogenase (LDH) activities compared to the cont rol. The results indicate that paracetamol is led to significant decrease in the c oncentration of Na + and K + and increase of Ca 2+ in the serum compared to the control. Coadministra tion of vitamin C and β -glucan with paracetamol reversed these changes of haematol ogical and biochemical parameters and diminished the toxic effects of paracetamol. Th e obtained results indicated that the concentration of LPO in erythrocytes significantly increased in, while the concentration of GSH significantly decreased in the group treated with paracetamol compared to control group. Coadministration of vitamin C and β -glucan with paracetamol reversed paracetamol-induced alterations in these oxidative stress parameters. This study suggests that paracetamol has significant prooxidative effec ts and may disrupt oxidant/antioxidant balance in erythrocytes. Furthermore, coadministrat ion with vitamin C and β -glucan have protective effects on paracetamol-induced oxidative damage and haematotoxicity.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173041/RS//
dc.rightsopenAccess
dc.sourceKragujevac Journal of Science
dc.subjectParacetamol
dc.subjectVitamin C β-glucan
dc.subjectOxidative stress
dc.subjectHaemato-biochemical parameters
dc.subjectErythrocytes
dc.titleParacetamol-induced changes of haemato-biochemical and oxidative stress parameters in rat blood: protective role of vitamin C and betaglucan
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМилошевић, Марија Д.; Саичић, Зорица; Штајн, Aндраш Ш.; Огњановић, Бранка И.; Пауновић, Милица Г.; Матић, Милош М.;
dc.rights.holder© Faculty of Science, University of Kragujevac
dc.citation.volume38
dc.description.otherKragujevac Journal of Science (2016), 38: 135-146
dc.citation.apaMatić, M. M., Milošević, M. D., Paunović, M. G., Ognjanović, B. I., Štajn, A. Š., & Saičić, Z. S. (2016). Paracetamol-induced changes of haemato-biochemical and oxidative stress parameters in rat blood: protective role of vitamin C and betaglucan. Kragujevac Journal of Science, 38, 135–146.
dc.citation.vancouverMatić MM, Milošević MD, Paunović MG, Ognjanović BI, Štajn AŠ, Saičić ZS. Paracetamol-induced changes of haemato-biochemical and oxidative stress parameters in rat blood: protective role of vitamin C and betaglucan. Kragujev J Sci. 2016;38:135–46.
dc.citation.spage135
dc.citation.epage146
dc.type.versionpublishedVersionen
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs/bitstream/id/612/bitstream_612.pdf
dc.citation.rankM53


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