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dc.creatorDevrnja, Nina
dc.creatorAnđelković, Boban
dc.creatorAranđelović, Sandra
dc.creatorRadulović, Siniša
dc.creatorSoković, Marina
dc.creatorKrstić Milošević, Dijana
dc.creatorRistić, Mihailo
dc.creatorĆalić, Dušica
dc.date.accessioned2017-11-23T11:28:29Z
dc.date.issued2017
dc.identifier.issn0254-06299
dc.identifier.urihttp://linkinghub.elsevier.com/retrieve/pii/S0254629916339928
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/2721
dc.description.abstractChemical composition of essential oil (EO) and methanol extracts (MEs) from different parts of Tanacetum vulgare L. plant was analyzed and investigated for potential biological activities and correlated with the main constituents detected in EO and MEs. The EO was characterized by a high content of oxygenated monoterpenes with trans-chrysanthenyl acetate as major compound. All MEs were characterized by neochlorogenic, 3,5-O-dicaffeoylquinic and caffeoylquinic acids. High phenolic content in MEs correlated to high antioxidant capacity, especially for roots. Tansy EO showed strong activity against the most of tested fungi and was efficient as bifonazole and ketoconazole, while the most sensitive bacteria were Gram-negative E. coli and E. cloacae. All MEs showed fungistatic and fungicidal effects against all of the eight tested fungi, but the antimicrobial activity was higher against Gram-positive bacteria. Additionally, shown for the first time, MEs of leaves and flowers exhibited a strong antiproliferative effect on human cervical adenocarcinoma (HeLa) cells, causing cell shrinkage and detachment. In the present study, the Tansy extracts and essential oil with low thujone content can provide a very promising and effective alternative in the field of antimicrobial applications and food preservation. The Tansy MEs possess a high antioxidant potential with phenolic acids being a major radical scavenging contributor with the proved antiproliferative activity to HeLa cells.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173015/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.rightsopenAccess
dc.sourceSouth African Journal of Botany
dc.subjectAntimicrobial effect
dc.subjectAntioxidant activity
dc.subjectCytotoxicity
dc.subjectEssential oil
dc.subjectMethanol extracts
dc.subjectTanacetum vulgare L.
dc.titleComparative studies on the antimicrobial and cytotoxic activities of Tanacetum vulgare L. essential oil and methanol extracts
dc.typearticle
dc.rights.licenseBY
dcterms.abstractЋалић, Душица; Соковић, Марина; Крстић Милошевић, Дијана; Деврња, Нина; Aнђелковић, Бобан; Aранђеловић, Сандра; Радуловић, Синиша; Ристић, Михаило;
dc.rights.holder© 2017 SAAB
dc.citation.volume111
dc.description.otherSouth African Journal of Botany (2017), 111: 212-221
dc.identifier.doi10.1016/j.sajb.2017.03.028
dc.identifier.scopus2-s2.0-85016236835
dc.identifier.wos000405251800027
dc.citation.apaDevrnja, N., Anđelković, B., Aranđelović, S., Radulović, S., Soković, M., Krstić-Milošević, D., Ristić, M., et al. (2017). Comparative studies on the antimicrobial and cytotoxic activities of Tanacetum vulgare L. essential oil and methanol extracts. South African Journal of Botany, 111, 212–221.
dc.citation.vancouverDevrnja N, Anđelković B, Aranđelović S, Radulović S, Soković M, Krstić-Milošević D, Ristić M, Ćalić D. Comparative studies on the antimicrobial and cytotoxic activities of Tanacetum vulgare L. essential oil and methanol extracts. South African J Bot. 2017;111:212–21.
dc.citation.spage212
dc.citation.epage221
dc.type.versionpublishedVersionen
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs/bitstream/id/3312/bitstream_3312.pdf
dc.citation.rankM22


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