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dc.creatorŠavikin, Katarina P.
dc.creatorKrstić Milošević, Dijana
dc.creatorMenković, Nebojša R.
dc.creatorBeara, Ivana N.
dc.creatorMrkonjić, Zorica O.
dc.creatorPljevljakušić, Dejan S.
dc.date.accessioned2017-11-23T11:32:09Z
dc.date.available2900-01-01
dc.date.issued2017
dc.identifier.issn1934-578X
dc.identifier.urihttp://www.naturalproduct.us/
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/2756
dc.description.abstractThe present study was designed to define the phenolic content, antioxidant and anti-inflammatory activity of Crateagus orientalis Pall. Ex M. Bieb., traditionally used by local people in southern parts of F.Y.R. Macedonia. The presence and content of 7 phenolics in ethanolic extracts of leaves and berries were studied using HPLC-DAD, where the most dominant compounds were hyperoside, isoquercitrin and chlorogenic acid. The leaf extract was more effective as a DPPH radical scavenger (IC50 = 29.7 μg/g) than the berry extract, as well as in the relative reducing power on Fe3+. Anti-inflammatory potential was studied by means of cyclooxygenase-1 (COX-1) and 12-lipoxygenase (12-LOX) inhibitory activity; both extracts evinced activity. Furthermore, C. orientalis leaf extract showed a concentration dependent inhibition of COX-1 pathway products 12-HHT and TXB2, reaching IC50 values below the lowest applied concentration (68.9% and 55.2% of 12-HHT and TXB2 production inhibition, respectively, at concentration of 0.4 mg/mL). Although inhibitors such as acetylsalicylic acid and quercetin showed higher activity, this study demonstrates that the investigated extracts are potential anti-inflammatory agents.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46013/RS//
dc.rightsrestrictedAccess
dc.sourceNatural Product Communications
dc.subjectAnti-inflammatory
dc.subjectHawthorn
dc.subjectHyperoside
dc.subjectPhenolics
dc.subjectRadical scavenging
dc.subjectReducing power
dc.titleCrataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity
dc.typeconferenceObject
dc.rights.licenseARR
dcterms.abstractШавикин, Катарина П.; Крстић Милошевић, Дијана; Пљевљакушић, Дејан С.; Мркоњић, Зорица О.; Беара, Ивана Н.; Менковић, Небојша Р.;
dc.rights.holder© Natural Product Incorporation
dc.citation.issue2
dc.citation.volume12
dc.identifier.doi10.1177/1934578x1701200204
dc.identifier.scopus2-s2.0-85019124206
dc.identifier.wos000395229200006
dc.citation.apaŠavikin, K. P., Krstić-Milošević, D., Menković, N. R., Beara, I. N., Mrkonjić, Z. O., & Pljevljakušić, D. S. (2017). Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity. Natural Product Communications, 12(2), 159–162.
dc.citation.vancouverŠavikin KP, Krstić-Milošević D, Menković NR, Beara IN, Mrkonjić ZO, Pljevljakušić DS. Crataegus orientalis leaves and berries: Phenolic profiles, antioxidant and anti-inflammatory activity. Nat Prod Commun. 2017;12(2):159–62.
dc.citation.spage159
dc.citation.epage162
dc.type.versionpublishedVersionen
dc.citation.rankM23


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