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dc.creatorArambašić Jovanović, Jelena
dc.creatorMihailović, Mirjana
dc.creatorGrdović, Nevena
dc.creatorDinić, Svetlana
dc.creatorPoznanović, Goran
dc.creatorVidaković, Melita
dc.creatorUskoković, Aleksandra
dc.creatorMujić, Ibrahim
dc.date.accessioned2017-11-23T11:20:14Z
dc.date.available2017-11-23T11:20:14Z
dc.date.issued2017
dc.identifier.issn1663-9812
dc.identifier.urihttp://journal.frontiersin.org/article/10.3389/fphar.2017.00793/full
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/2885
dc.description.abstractThe present study aimed to investigate the beneficial effects of the treatment with extracts from the edible mushroom Lactarius deterrimus (Ld) and the chestnut Castanea sativa (Cs), separately and in combination (MIX Ld/Cs), on oxidative stress and advanced glycation end-product (AGE)-mediated hepatorenal injury in a rat model of streptozotocin (STZ)-induced diabetes by examining pathways responsible for maintenance of redox homeostasis. An experimental model of diabetes was induced in rats by the administration of 40 mg/kg STZ intraperitoneally (i.p.) for five consecutive days. The examined extracts were applied separately at a dose of 60 mg/kg i.p. and in combination (60 mg/kg each extract; i.p.) for four weeks, starting from the last day of STZ administration. The improvement of hepatorenal function in diabetic rats treated with the extracts was associated with an improved glycemic and lipid status and suppression of oxidative stress and thereby oxidative damage of lipids and DNA. Besides the fact that both extracts inhibited protein glycation and AGE formation in vitro, they also reduced non-enzymatic glycosylation in diabetic rats in vivo. The observed antiglycation activity of the examined extracts (separately and in combination) was accompanied with the inhibition of CML-mediated RAGE/NF-κB activation and reduction of enzymatic O-GlcNAcylation in liver and kidney tissues of diabetic rats. Taken together, these results reveal that the administration of chestnut and mushroom extracts, either individually or together, activates a coordinated cytoprotective response against diabetes-induced hepatorenal injury not only through recovery of the antioxidant defense system of the cell, but also through a marked antiglycation activity.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173020/RS//
dc.rightsopenAccess
dc.sourceFrontiers in Pharmacology
dc.subjectDiabetes
dc.subjectLactarius deterrimus
dc.subjectCastanea sativa
dc.subjectHepatorenal protection
dc.subjectAntioxidant and antiglycating
dc.titleEvaluation of the Antioxidant and Antiglycation Effects of Lactarius deterrimus and Castanea sativa Extracts on Hepatorenal Injury in Streptozotocin-Induced Diabetic Rats
dc.typearticle
dc.rights.licenseBY
dcterms.abstractУскоковић, Aлександра; Михаиловић, Мирјана; Видаковић, Мелита; Aрамбашић Јовановић, Јелена; Познановић, Горан; Мујић, Ибрахим; Динић, Светлана; Грдовић, Невена;
dc.rights.holder© 2017 Jovanović, Mihailović, Uskoković, Grdović, Dinić, Poznanović, Mujić and Vidaković
dc.citation.volume8
dc.identifier.doi10.3389/fphar.2017.00793
dc.identifier.scopus2-s2.0-85032572769
dc.identifier.wos000414017300001
dc.citation.apaArambašić Jovanović, J., Mihailović, M., Uskoković, A. S., Grdović, N., Dinić, S., Poznanović, G., Mujić, I., et al. (2017). Evaluation of the Antioxidant and Antiglycation Effects of Lactarius deterrimus and Castanea sativa Extracts on Hepatorenal Injury in Streptozotocin-Induced Diabetic Rats. Frontiers in Pharmacology, 8, 793.
dc.citation.vancouverArambašić Jovanović J, Mihailović M, Uskoković AS, Grdović N, Dinić S, Poznanović G, Mujić I, Vidaković M. Evaluation of the Antioxidant and Antiglycation Effects of Lactarius deterrimus and Castanea sativa Extracts on Hepatorenal Injury in Streptozotocin-Induced Diabetic Rats. Front Pharmacol. 2017;8:793.
dc.citation.spage793
dc.citation.epage793
dc.type.versionpublishedVersionen
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs//bitstream/id/2373/FrontPharmacol_2017_8_793.pdf
dc.citation.rankM21


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