Uloga hem oksigenaze 1 i NF-kB u mrkom masnom tkivu pacova - uticaj azot oksida
The role of heme oxygenase 1 and NF-kB in interscapular brown adipose tissue: The influence of nitric oxide
Buzadžić, Biljana J.
Article (Published version)
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The male Mill Hill hybrid hooded rats were divided into three main groups one received L-arginine HCl (2.25%), another Nω-nitro-L-arginine methyl ester (L-NAME HCl 0.01%), in drinking water for 45 days and the third group was a control. All groups additionally were divided into two subgroups: one - housed at 22 ± 1 °C and another - at 4 ± 1 °C. HO-1 and NF-kB were identified using immunohistochemistry. Present data disclosed parallelism between HO-1 and NF-kB immunopositivity in IBAT of rats kept at room and low temperature. At room temperature, immunopositivities of HO-1 and NF-kB were increased in L-arginine-treated group when compared to the control, while the strongest immunopositivities and their translocation into nuclei were detected in L-NAME-treated-group. Cold markedly diminished both HO-1 and NF-kB immunopositivity.
Keywords:interscapular brown adipose tissue; nitric oxide synthesis; heme oxygenase; NF-kB; redox regulation
Source:Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 2006, 42, 3, 185-192