Show simple item record

dc.creatorĆirić, Jelena
dc.creatorLazić, Katarina
dc.creatorKapor, Slobodan
dc.creatorPerović, Milka
dc.creatorPetrović, Jelena
dc.creatorPešić, Vesna
dc.creatorKanazir, Selma
dc.creatorŠaponjić, Jasna
dc.date.accessioned2017-12-08T12:09:24Z
dc.date.available2019-05-21
dc.date.issued2018
dc.identifier.issn0166-4328
dc.identifier.urihttp://linkinghub.elsevier.com/retrieve/pii/S0166432817312391
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/29170000
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/2932
dc.description.abstractIn order to find out the possible earliest biomarkers of Parkinson's disease (PD) cholinopathy, we followed the impact of bilateral pedunculopontine tegmental nucleus (PPT) lesion in rat on: the cortical and hippocampal sleep/wake states architectures, all sleep states related EEG microstructures, sleep spindles, the basal and stimulated locomotor activity. Sleep and basal locomotor activity in adult Wistar rats were followed during their inactive circadian phase, and throughout the same aging period. The bilateral PPT lesions were done by 0.1M ibotenic acid (IBO) during the surgical procedure for implantation of the electroencephalographic (EEG) and electromyographic (EMG) electrodes for chronic sleep recording. The cholinergic neuronal loss was identified by NADPH - diaphorase histochemistry. After all sleep and behavioral recording sessions, the locomotor activity was stimulated by d-amphetamine (d-AMPH) and the neuronal activity of striatum was followed by c-Fos immunolabeling. Impaired cholinergic innervation from the PPT was expressed earlier as sleep disorder then as movement disorder, and it was the earliest and long-lasting at hippocampal and thalamo-cortical level, and followed by a delayed "hypokinesia". This severe impact of a tonically impaired PPT cholinergic innervation was evidenced as the cholinergic interneuronal loss of the caudate putamen and as a suppressed c-Fos expression after stimulation by d-AMPH. In order how they occurred, the hippocampal non rapid eye movement (NREM) sleep disorder, altered high voltage sleep spindle (HVS) dynamics during rapid eye movement (REM) sleep in the hippocampus and motor cortex, and "hypokinesia" may serve as the biomarkers of PD cholinopathy onset and progression.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173022/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173056/RS//
dc.rightsrestrictedAccess
dc.sourceBehavioural Brain Research
dc.subjectHigh voltage sleep spindles
dc.subjectLocomotor activity
dc.subjectParkinson’s disease
dc.subjectPedunculopontine tegmental nucleus
dc.subjectSleep
dc.subjectc-Fos
dc.titleSleep disorder and altered locomotor activity as biomarkers of the Parkinson's disease cholinopathy in rat
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractЛазић, Катарина; Каназир, Селма; Капор, Слободан; Шапоњић, Јасна; Пешић, Весна; Петровић, Јелена; Перовић, Милка; Ћирић, Јелена;
dc.rights.holder© 2017 Elsevier B.V.
dc.citation.volume339
dc.identifier.doi10.1016/j.bbr.2017.11.021
dc.identifier.pmid29170000
dc.identifier.scopus2-s2.0-85034764500
dc.identifier.wos000424173300010
dc.citation.apaCiric, J., Lazic, K., Kapor, S., Perovic, M., Petrovic, J., Pesic, V., Kanazir, S., et al. (2018). Sleep disorder and altered locomotor activity as biomarkers of the Parkinson’s disease cholinopathy in rat. Behavioural brain research, 339, 79-92.
dc.citation.vancouverCiric J, Lazic K, Kapor S, Perovic M, Petrovic J, Pesic V, Kanazir S, Saponjic J. Sleep disorder and altered locomotor activity as biomarkers of the Parkinson’s disease cholinopathy in rat. Behav Brain Res. 2018;339:79-92.
dc.citation.spage79
dc.citation.epage92
dc.type.versionpublishedVersion
dc.citation.rankM21


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record