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dc.creatorNestorović Živković, Jasmina
dc.creatorŽivković, Suzana
dc.creatorŠiler, Branislav
dc.creatorAničić, Neda
dc.creatorDmitrović, Slavica
dc.creatorDivac-Rankov, Aleksandra
dc.creatorGiba, Zlatko
dc.creatorMišić, Danijela
dc.date.accessioned2018-03-29T08:51:18Z
dc.date.available2018-03-29T08:51:18Z
dc.date.issued2018
dc.identifier.urihttp://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641700026N
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/3017
dc.identifier.urihttp://www.serbiosoc.org.rs/arch/index.php/abs/article/view/1881
dc.description.abstractMethanol extracts of three endemic Nepeta species were analyzed for their main secondary metabolites, terpenes and phenolics, and further investigated for antioxidant capacity and embryonic toxicity in zebrafish. UHPLC/DAD/(±) HESI-MS/MS analysis showed that the dominant compound in N. rtanjensis was trans,cis-nepetalactone, the cis,trans isomer of this monoterpene lactone was dominant in N. sibirica, while nepetalactone was detected only in traces in N. nervosa. In all investigated species, rosmarinic acid was the dominant phenolic compound, while other identified phenolic acids (chlorogenic, neochlorogenic and caffeic) were present in considerably lower amounts. ABTS and DPPH assays showed that the methanol extracts of N. rtanjensis, N. sibirica and especially N. nervosa possessed strong antioxidant activities, with the FRAP assay revealing high ferric-reducing abilities for all three tested species. Such a strong antioxidant potential, especially as manifested in the DPPH and FRAP assays, can be attributed to phenolic acids, and in the first place to rosmarinic acid. Increased lethality of zebrafish embryos in any of the treatments was not observed, but several toxic effects on embryonic development were recorded, such as pericardial and yolk sac edema. As in other Nepeta species, the three studied endemic species possessed a great potential for food conservation or as medicinal supplements if applied in optimized concentrations; however, alternative sources of plant material (e.g. field cultivation) should be established bearing in mind their vulnerability in nature.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173024/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173008/RS//
dc.rightsopenAccess
dc.sourceArchives of Biological Sciences
dc.sourceArchives of Biological Sciences
dc.subjectNepeta rtanjensis
dc.subjectNepeta sibirica
dc.subjectNepeta nervosa
dc.subjectNepetalactone
dc.subjectPhenolic acids
dc.titleDifferences in bioactivity of three endemic Nepeta species arising from main terpenoid and phenolic constituents
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractДивац-Ранков, Aлександра; Гиба, Златко; Живковић, Сузана; Шилер, Бранислав; Aничић, Неда; Дмитровић, Славица; Мишић, Данијела; Несторовић-Живковић, Јасмина;
dc.rights.holder© 2018 by the Serbian Biological Society
dc.citation.issue1
dc.citation.volume70
dc.identifier.doi10.2298/ABS170616026N
dc.identifier.scopus2-s2.0-85043682981
dc.identifier.wos000428370100007
dc.citation.apaNestorović-Živković, J., Živković, S., Šiler, B., Aničić, N., Dmitrović, S., Divac-Rankov, A., Giba, Z., et al. (2018). Differences in bioactivity of three endemic Nepeta species arising from main terpenoid and phenolic constituents. Archives of Biological Sciences, 70(1), 63–76.
dc.citation.vancouverNestorović-Živković J, Živković S, Šiler B, Aničić N, Dmitrović S, Divac-Rankov A, Giba Z, Mišić D. Differences in bioactivity of three endemic Nepeta species arising from main terpenoid and phenolic constituents. Arch Biol Sci. 2018;70(1):63–76.
dc.citation.spage63
dc.citation.epage76
dc.type.versionpublishedVersionen
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs//bitstream/id/4172/ABS-70-1-063.pdf
dc.citation.rankM23


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