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dc.creatorVujičić, Milica
dc.creatorSaksida, Tamara
dc.creatorDespotović, Sanja
dc.creatorSoković Bajić, Svetlana
dc.creatorLalić, Ivana
dc.creatorKoprivica, Ivan
dc.creatorGajić, Dragica
dc.creatorGolić, Natasa
dc.creatorTolinački, Maja
dc.creatorStojanović, Ivana
dc.date.accessioned2018-05-17T08:59:03Z
dc.date.available2018-05-17T08:59:03Z
dc.date.issued2018
dc.identifier.urihttp://www.nature.com/articles/s41598-018-24706-3
dc.identifier.urihttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC5910418
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/3049
dc.description.abstractMacrophage migration inhibitory factor (MIF) is a multifunctional protein that is involved in the development of gut-related inflammation. To investigate the role of MIF in the function of the intestinal barrier, we have explored intestinal permeability and gut-associated immune response in MIF-deficient (MIF-KO) mice. The absence of MIF provoked impairment of tight and adherens epithelial junctions in the colon through the disturbance of E-cadherin, zonula occludens-1, occludin and claudin-2 expression, which lead to the increase of intestinal barrier permeability. In these circumstances the diversity and content of gut microbiota in MIF-KO mice was considerably different compared to wild type mice. This change in microbiota was accompanied by an increased intestinal IgA concentration and a higher production of pro-inflammatory cytokines TNF and IFN-γ in mesenteric lymph nodes of MIF-KO mice. The forced changes of microbiota executed by antibiotics prevented the "leakage" of the barrier in MIF-KO mice, probably through up-regulation of occludin expression and normalization of cellular pore diameters. In addition, cytokine secretion was normalized after the treatment with antibiotics. These results suggest that MIF participates in the maintenance of physiological microbiota diversity and immunosurveillance, which in turn enables the proper intestinal barrier function.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS//
dc.rightsopenAccess
dc.sourceScientific Reports
dc.titleThe Role of Macrophage Migration Inhibitory Factor in the Function of Intestinal Barrier.
dc.typearticleen
dc.rights.licenseBY
dcterms.abstractГолић, Натаса; Саксида, Тамара; Копривица, Иван; Толиначки, Маја; Стојановић, Ивана; Вујичић, Милица; Деспотовић, Сања; Соковић Бајић, Светлана; Лалић, Ивана; Гајић, Драгица;
dc.rights.holder© 2018 The Author(s).
dc.citation.issue1
dc.citation.volume8
dc.identifier.doi10.1038/s41598-018-24706-3
dc.identifier.pmid29679061
dc.identifier.scopus2-s2.0-85045886334
dc.identifier.wos000430537800014
dc.citation.apaVujicic, M., Saksida, T., Despotovic, S., Bajic, S. S., Lalić, I., Koprivica, I., … Stojanovic, I. (2018). The Role of Macrophage Migration Inhibitory Factor in the Function of Intestinal Barrier. Scientific Reports, 8(1), 6337.
dc.citation.vancouverVujicic M, Saksida T, Despotovic S, Bajic SS, Lalić I, Koprivica I, Gajic D, Golic N, Tolinacki M, Stojanovic I. The Role of Macrophage Migration Inhibitory Factor in the Function of Intestinal Barrier. Sci Rep. 2018;8(1):6337.
dc.citation.spage6337
dc.type.versionpublishedVersionen
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs//bitstream/id/4245/SciRep_2018_8_1_6337.pdf


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