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dc.creatorGrdović, Nevena
dc.creatorDinić, Svetlana
dc.creatorArambašić Jovanović, Jelena
dc.creatorMihailović, Mirjana
dc.creatorUskoković, Aleksandra
dc.creatorMarković, Jelena
dc.creatorPoznanović, Goran
dc.creatorVidović, Senka
dc.creatorZeković, Zoran
dc.creatorMujić, Aida
dc.creatorMujić, Ibrahim
dc.creatorVidaković, Melita
dc.date.accessioned2018-12-12T11:23:33Z
dc.date.available2018-12-12T11:23:33Z
dc.date.issued2012
dc.identifier.urihttp://www.journals.cambridge.org/abstract_S0007114511006702
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/3198
dc.description.abstractPancreatic β-cell death or dysfunction mediated by oxidative stress underlies the development and progression of diabetes mellitus. In the present study, we tested extracts from the edible mushroom Lactarius deterrimus and the chestnut Castanea sativa, as well as their mixture (MIX Ld/Cs), for potential beneficial effects on streptozotocin (STZ)-induced pancreatic β-cell death. Analysis of chelating effects, reducing power and radical-scavenging assays revealed strong antioxidant effects of the C. sativa extract and MIX Ld/Cs, while the L. deterrimus extract displayed a weak to moderate effect. The antioxidative effect of the chestnut extract corresponds with the high content of phenolics and flavonoids identified by HPLC analysis. In contrast, the mushroom extract contains relatively small amounts of phenols and flavonoids. However, both extracts, and especially their combination MIX Ld/Cs, increased cell viability after the STZ treatment as a result of a significant reduction of DNA damage and improved redox status. The chestnut extract and MIX Ld/Cs significantly lowered the STZ-induced increases in superoxide dismutase and catalase activities, while the mushroom extract had no impact on the activities of these antioxidant enzymes. However, the L. deterrimus extract exhibited good NO-scavenging activity. Different mechanisms that underlie antioxidant effects of the mushroom and chestnut extracts were discussed. When combined as in the MIX Ld/Cs, the extracts exhibited diverse but synergistic actions that ultimately exerted beneficial and protective effects against STZ-induced pancreatic β-cell death.
dc.languageen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173020/RS//
dc.rightsopenAccess
dc.sourceThe British Journal of Nutrition
dc.subjectAntioxidant activity
dc.subjectCastanea sativa
dc.subjectCytoprotection
dc.subjectLactarius deterrimus
dc.subjectRin-5F cells
dc.titleThe protective effect of a mix of Lactarius deterrimus and Castanea sativa extracts on streptozotocin-induced oxidative stress and pancreatic β-cell death
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractВидовић, Сенка; Видаковић, Мелита; Зековић, Зоран; Марковић, Јелена; Мујић, Aида; Мујић, Ибрахим; Грдовић, Невена; Динић, Светлана; Aрамбашић, Јелена; Михаиловић, Мирјана; Ускоковић, Aлександра; Познановић, Горан;
dc.rights.holder© 2011 The Authors.
dc.citation.issue7
dc.citation.volume108
dc.identifier.doi10.1017/S0007114511006702
dc.identifier.pmid22186906
dc.identifier.scopus2-s2.0-84869464304
dc.identifier.wos000309947600004
dc.citation.spage1163
dc.citation.epage1176
dc.type.versionpublishedVersionen
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs//bitstream/id/4639/BrJNutr_2012_108_7_1163-1176.pdf
dc.citation.rankM21


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