Show simple item record

dc.creatorĐedović, Neda
dc.creatorJevtić, Bojan
dc.creatorMansilla, M. José
dc.creatorPetković, Filip
dc.creatorBlaževski, Jana
dc.creatorTimotijević, Gordana
dc.creatorNavarro-Barriuso, Juan
dc.creatorMartinez-Caceres, Eva
dc.creatorMostarica Stojković, Marija
dc.creatorMiljković, Đorđe
dc.date2020-02-08
dc.date.accessioned2019-02-25T12:24:25Z
dc.date.available2020-02-08
dc.date.issued2019
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0171298518302201?via%3Dihub
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/3265
dc.description.abstractDendritic cells (DC) are responsible for the initiation and shaping of the adaptive immune response and are in the focus of autoimmunity research. We were interested in comparison of DC obtained from autoimmunity-prone Dark Agouti (DA) rats and autoimmunity-resistant Albino Oxford (AO) rats. DC were generated from bone marrow precursors and matured (mDC) by lipopolysaccharide. Tolerogenic DC (tolDC) obtained by vitamin D3 treatment were studied in parallel. Profile of cytokine production was different in AO and DA mDC and tolDC. Expression of MHC class II molecules and CD86 were higher in DA DC, while vitamin D3 reduced their expression in dendritic cells of both strains. Allogeneic proliferation of CD4+ T cells was reduced by AO tolDC, but not with DA tolDC in comparison to respective mDC. Finally, expression of various genes identified as differentially expressed in human mDC and tolDC was also analyzed in AO and DA DC. Again, AO and DA DC differed in the expression of the analyzed genes. To conclude, AO and DA DC differ in production of cytokines, expression of antigen presentation-related molecules and in regulation of CD4+ T proliferation. The difference is valuable for understanding the divergence of the strains in their susceptibility to autoimmunity.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS//
dc.relationprojects PI14/01175 and PI17/01521
dc.relationShort Term Scientific Missions through A FACTT network (Cost Action BM1305: www.afactt.eu)
dc.rightsembargoedAccess
dc.sourceImmunobiology
dc.subjectAlbino Oxford rats
dc.subjectAllogeneic proliferation
dc.subjectAutoimmunity
dc.subjectDark agouti rats
dc.subjectDendritic cells
dc.titleComparison of dendritic cells obtained from autoimmunty-prone and resistant rats.
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractБлажевски, Јана; Ђедовић, Неда; Јевтић, Бојан; Петковић, Филип; Мансилла, М. Јосé; Наварро-Барриусо, Јуан; Мартинез-Цацерес, Ева; Миљковић, Ђорђе; Мостарица Стојковић, Марија; Тимотијевић, Гордана;
dc.rights.holder© 2019 Elsevier GmbH
dc.identifier.doi10.1016/j.imbio.2019.01.001
dc.identifier.pmid30765133
dc.identifier.scopus2-s2.0-85061255964
dc.identifier.wos000473836000019
dc.citation.apaDjedovic, N., Jevtić, B., Mansilla, M. J., Petković, F., Blaževski, J., Timotijević, G., … Miljković, Đ. (2019). Comparison of dendritic cells obtained from autoimmunty-prone and resistant rats. Immunobiology, DOI:10.1016/j.imbio.2019.01.001.
dc.citation.vancouverDjedovic N, Jevtić B, Mansilla MJ, Petković F, Blaževski J, Timotijević G, Navarro-Barriuso J, Martinez-Caceres E, Mostarica Stojković M, Miljković Đ. Comparison of dendritic cells obtained from autoimmunty-prone and resistant rats. Immunobiology. 2019;DOI:10.1016/j.imbio.2019.01.001.
dc.type.versionacceptedVersion
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs/bitstream/id/4815/Immunobiology_2019b.pdf
dc.citation.rankM22


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record