Novel antimicrobial agents' discovery among the steroid derivatives.
Authors:Nadaraia, Nanuli Sh.
Amiranashvili, Lela Sh.
Kakhabrishvili, Meri L.
Barbakadze, Nana N.
Article (Published version)
© 2019 Published by Elsevier Inc.
MetadataShow full item record
Fourteen steroid compounds were in silico evaluated using computer program PASS as antimicrobial agents. The experimental studies evaluation revealed that all compounds have good antibacterial activity with MIC at range of 0.003-0.96 mg/mL and MBC 0.06-1.92 mg/mL. Almost all compounds except of compound 4 (3β-acetoxy-1/-p-chlorophenyl-3/-methyl-5α-androstano[17,16-d]pyrazoline) were more potent than Ampicillin, and they were equipotent or more potent than Streptomycine. All compounds exhibited good antifungal activity with MIC at 0.003-0.96 mg/mL and MFC at 0.006-1.92 mg/mL but with different sensitivity against fungi tested. According to docking studies 14-alpha demethylase inhibition may be responsible for antifungal activity. Prediction of toxicity by PROTOX and GUSAR revealed that compounds have low toxicity and can be considered as potential lead compounds for the further studies.
Keywords:Antibacterial; Antifungal; N-containing 5α-steroids; Open TOX; PASS
Source:Steroids, 2019, 144, 52-65
- University of KwaZulu-Natal (UKZN), Pietermaritzburg campus, South Africa