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dc.creatorBuzharevski, Antonio
dc.creatorPaskaš, Svetlana
dc.creatorLaube, Markus
dc.creatorLönnecke, Peter
dc.creatorNeumann, Wilma
dc.creatorMurganić, Blagoje
dc.creatorMijatović, Sanja
dc.creatorMaksimović-Ivanić, Danijela
dc.creatorPietzsch, Jens
dc.creatorHey-Hawkins, Evamarie
dc.date.accessioned2019-06-19T13:29:35Z
dc.date.available2019-06-19T13:29:35Z
dc.date.issued2019
dc.identifier.urihttp://pubs.acs.org/doi/10.1021/acsomega.9b00412
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/3366
dc.description.abstractKetoprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) that also exhibits cytotoxic activity against various cancers. This makes ketoprofen an attractive structural lead for the development of new NSAIDs and cytotoxic agents. Recently, the incorporation of carboranes as phenyl mimetics in structures of established drugs has emerged as an attractive strategy in drug design. Herein, we report the synthesis and evaluation of four novel carborane-containing derivatives of ketoprofen, two of which are prodrug esters with an nitric oxide-releasing moiety. One of these prodrug esters exhibited high cytostatic activity against melanoma and colon cancer cell lines. The most pronounced activity was found in cell lines that are sensitive to oxidative stress, which was apparently induced by the ketoprofen analogue.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS//
dc.rightsopenAccess
dc.sourceACS Omega
dc.sourceACS Omega
dc.titleCarboranyl Analogues of Ketoprofen with Cytostatic Activity against Human Melanoma and Colon Cancer Cell Lines
dc.typearticleen
dc.rights.licenseBY
dcterms.abstractМијатовић, Сања; Максимовић-Иванић, Данијела; Пиетзсцх, Јенс; Хеy-Хаwкинс, Евамарие; Бузхаревски, Aнтонио; Паскаш, Светлана; Лаубе, Маркус; Лöннецке, Петер; Неуманн, Wилма; Мурганић, Благоје;
dc.rights.holder© 2019 American Chemical Society
dc.citation.issue5
dc.citation.volume4
dc.identifier.doi10.1021/acsomega.9b00412
dc.identifier.scopus2-s2.0-85066094299
dc.identifier.wos000470094000104
dc.citation.apaBuzharevski, A., Paskas, S., Laube, M., Lönnecke, P., Neumann, W., Murganic, B., et al. (2019). Carboranyl Analogues of Ketoprofen with Cytostatic Activity against Human Melanoma and Colon Cancer Cell Lines. ACS Omega, 4(5), 8824–8833.
dc.citation.vancouverBuzharevski A, Paskas S, Laube M, Lönnecke P, Neumann W, Murganic B, Mijatovic S, Maksimovic-Ivanic D, Pietzsch J, Hey-Hawkins E. Carboranyl Analogues of Ketoprofen with Cytostatic Activity against Human Melanoma and Colon Cancer Cell Lines. ACS Omega. 2019;4(5):8824–33.
dc.citation.spage8824
dc.citation.epage8833
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs//bitstream/id/5079/ACSOmega_2019_4_5_8824-8833.pdf


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