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dc.creatorDavidović-Plavšić, Biljana
dc.creatorLukić, Nataša
dc.creatorNikolić-Kokić, Aleksandra
dc.creatorKukavica, Biljana
dc.date.accessioned2019-07-09T11:23:31Z
dc.date.available2019-07-09T11:23:31Z
dc.date.issued2019
dc.identifier.urihttp://www.doiserbia.nb.rs/Article.aspx?ID=0352-51391800115D
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/3396
dc.description.abstractThe aim of this work was to investigate the effect of the commercial formulation hemazin SC 500, an herbicide containing terbuthylazine as the active compound, on the isoenzyme patterns and activities of Cu-Zn superoxide dismutase (SOD1) and catalase (CAT), as well as on the glutathione S-transferase (GST) activity, in human erythrocytes in vitro. The human erythrocytes were treated with hemazin SC 500 over a broad range of terbuthylazine concentrations (37 nmol L-1– –37 mol L-1) for 1 and 3 h at a temperature of 37°C. Native electrophoresis of the control and treated samples revealed two SOD1 and one CAT isoform. Treatment did not affect the SOD1 and CAT isoenzyme profile, but induced a change in their activities. Terbuthylazine at lower concentration induced a significant increase of the total SOD1 activity and decreased the GST activity in samples incubated for 1 and 3 h. On the other hand, the highest increase in the CAT activity was observed for the sample treated for 1 h with a higher concentration of terbuthylazine. Hemazin SC 500 containing terbuthylazine induces changes in the erythrocyte antioxidative system whereby the response of individual enzymatic antioxidants depends on the concentration of the pesticide and the incubation time.
dc.relationMinistry of Science and Technology of the Republic of Srpska (19/6-020/961-24/15)
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectHerbicide
dc.subjectHemolysate
dc.subjectSOD1
dc.subjectCatalase
dc.subjectGlutathione-S-transferase
dc.subject.otherm23
dc.titleEffects of hemazin SC 500 (terbuthylazine) on antioxidative enzymes in human erythrocytes in vitro
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractКукавица, Биљана; Лукић, Наташа; Давидовић-Плавшић, Биљана; Николић-Кокић, Aлександра;
dc.rights.holder© 2019 Serbian Chemical Society
dc.citation.issue5
dc.citation.volume84
dc.identifier.doi10.2298/JSC181011115D
dc.identifier.scopus2-s2.0-85067251213
dc.identifier.wos000470107300002
dc.citation.apaDavidović-Plavšić, B., Lukić, N., Nikolić-Kokić, A., & Kukavica, B. (2019). Effects of hemazin SC 500 (terbuthylazine) on antioxidative enzymes in human erythrocytes in vitro. Journal of the Serbian Chemical Society, 84(5), 455–465.
dc.citation.vancouverDavidović-Plavšić B, Lukić N, Nikolić-Kokić A, Kukavica B. Effects of hemazin SC 500 (terbuthylazine) on antioxidative enzymes in human erythrocytes in vitro. J Serbian Chem Soc. 2019;84(5):455–65.
dc.citation.spage455
dc.citation.epage465
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs/bitstream/id/5161/bitstream_5161.pdf
dc.citation.rankM23


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