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dc.creatorĐurašević, Siniša
dc.creatorNikolić, Gorana
dc.creatorZaletel, Ivan
dc.creatorGrigorov, Ilijana
dc.creatorMemon, Lidija
dc.creatorMitić-Ćulafić, Dragana
dc.creatorVujović, Predrag
dc.creatorĐorđević, Jelena
dc.creatorTodorović, Zoran
dc.date.accessioned2019-11-14T08:46:46Z
dc.date.available2019-11-14T08:46:46Z
dc.date.issued2020
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1756464619305250?via%3Dihub
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/3512
dc.identifier.urihttps://s100.copyright.com/AppDispatchServlet?publisherName=ELS&contentID=S1756464619305250&orderBeanReset=true
dc.description.abstractNon-diabetic and alloxan-induced diabetic rats were fed with standard laboratory food enriched with 20% virgin coconut oil for 16 weeks. In non-diabetic animals coconut oil improved insulin sensitivity and ability to control glycaemia and decreased the serum triglycerides for almost 50% in comparison with controls. Supplementation with coconut oil caused liver steatosis in both non-diabetic and diabetic animals. However, the severity of steatosis was lower in diabetic animals compared to non-diabetic animals. Coconut oil had no effects on heart histology, ascending and abdominal aorta wall thickening and atherosclerotic plaques development neither in non-diabetic nor in diabetic animals. While alloxan treatment caused Type I diabetes in rats, supplementation with coconut oil in combination with the alloxan unexpectedly resulted in Type II diabetes. The development of severe insulin resistance and deterioration in serum lipid profile implied that the use of coconut oil is contraindicated in diabetic condition.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173023/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173020/RS//
dc.rightsopenAccess
dc.sourceJournal of Functional Foods
dc.subjectAlloxan-induced diabetes
dc.subjectCoconut oil
dc.subjectGlucose homeostasis
dc.subjectLipid homeostasis
dc.subjectInflammation
dc.subjectRats
dc.titleDistinct effects of virgin coconut oil supplementation on the glucose and lipid homeostasis in non-diabetic and alloxan-induced diabetic rats
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractТодоровић, Зоран; Ђурашевић, Синиша; Залетел, Иван; Митић-Ћулафић, Драгана; Вујовић, Предраг; Ђорђевић, Јелена; Николић, Горана; Григоров, Илијана; Мемон, Лидија;
dc.rights.holder© 2019 Elsevier Ltd.
dc.citation.volume64
dc.identifier.doi10.1016/J.JFF.2019.103601
dc.identifier.scopus2-s2.0-85074477562
dc.identifier.wos000508491000021
dc.citation.apaĐurašević, S., Nikolić, G., Zaletel, I., Grigorov, I., Memon, L., Mitić-Ćulafić, D., et al. (2020). Distinct effects of virgin coconut oil supplementation on the glucose and lipid homeostasis in non-diabetic and alloxan-induced diabetic rats. Journal of Functional Foods, 103601
dc.citation.vancouverĐurašević S, Nikolić G, Zaletel I, Grigorov I, Memon L, Mitić-Ćulafić D, Vujović P, Đorđević J, Todorović Z. Distinct effects of virgin coconut oil supplementation on the glucose and lipid homeostasis in non-diabetic and alloxan-induced diabetic rats. J Funct Foods. 2020;64:103601.
dc.citation.spage103601
dc.type.versionpublishedVersion
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs/bitstream/id/6405/JFunctFoods_2020_64_103601.pdf
dc.citation.rankM21


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