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dc.creatorAničić, Neda
dc.creatorMatekalo, Dragana
dc.creatorSkorić, Marijana
dc.creatorNestorović Živković, Jasmina
dc.creatorPetrović, Luka
dc.creatorDragićević, Milan
dc.creatorDmitrović, Slavica
dc.creatorMišić, Danijela
dc.date.accessioned2020-03-30T15:58:03Z
dc.date.available2900-01-01
dc.date.issued2020
dc.identifier.issn0031-9422
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/32172017
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/3626
dc.description.abstractA number of Nepeta species (fam. Lamiaceae) are interesting medicinal crops for arid and semi-arid areas, due to their ability to maintain essential developmental and physiological processes and to rationalize their specialized metabolism under water deficit growth conditions. The present research is, to our knowledge, the first attempt to investigate the molecular background of the dehydration-induced changes in specialized metabolism of Nepeta species, which will help to understand relations between dehydration stress on one hand and biomass production and yield of nepetalactone (NL) on the other. During the 6 days exposure of Nepeta rtanjensis Diklić & Milojević and Nepeta argolica Bory & Chaub. ssp. argolica plants to PEG-induced dehydration stress under experimental in vitro conditions, decrease in transcript levels of the majority of 10 NL biosynthetic genes, and some of the 5 transcription factors (TFs) were recorded, simultaneously with the initial reduction in NL content. The two model species evidently employ similar strategies in response to severe dehydration stress; however N. rtanjensis is highlighted as the species more efficient in maintaining NL amounts in tissues. The results suggest trichome-specific and co-ordinately regulated NL biosynthesis at the level of gene expression, with trichome enriched MYC2 and YABBY5 TFs being the potential positive regulators. Manipulation of such TFs can be effective for engineering the NL biosynthetic pathway, and for the increased production of cis,trans-NL in N. argolica ssp. argolica and trans,cis-NL in N. rtanjensis.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173024/RS//
dc.rightsrestrictedAccess
dc.sourcePhytochemistry
dc.subjectDehydration stress
dc.subjectIridoid monoterpenoids
dc.subjectLamiaceae
dc.subjectNepeta argolica ssp. argolica
dc.subjectNepeta rtanjensis
dc.subjectNepetalactone biosynthesis
dc.subjectPEG
dc.subjectTranscription factors
dc.titleAlterations in nepetalactone metabolism during polyethylene glycol (PEG)-induced dehydration stress in two Nepeta species.
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractСкорић, Маријана; Несторовић Живковић, Јасмина; Петровић, Лука; Aничић, Неда; Матекало, Драгана; Драгићевић, Милан; Дмитровић, Славица; Мишић, Данијела;
dc.rights.holder© 2020 Elsevier Ltd
dc.citation.volume174
dc.identifier.doi10.1016/j.phytochem.2020.112340
dc.identifier.pmid32172017
dc.identifier.scopus2-s2.0-85081239043
dc.identifier.wos000529798600002
dc.citation.apaAničić, N., Matekalo, D., Skorić, M., Živković, J. N., Petrović, L., Dragićević, M., et al. (2020). Alterations in nepetalactone metabolism during polyethylene glycol (PEG)-induced dehydration stress in two Nepeta species. Phytochemistry, 174, 112340.
dc.citation.vancouverAničić N, Matekalo D, Skorić M, Živković JN, Petrović L, Dragićević M, Dmitrović S, Mišić D. Alterations in nepetalactone metabolism during polyethylene glycol (PEG)-induced dehydration stress in two Nepeta species. Phytochemistry. 2020;174:112340.
dc.citation.spage112340
dc.type.versionpublishedVersion
dc.citation.rankM21


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