Zaštitni efekat selena na antioksidacioni zaštitni sistem u krvi pacova tretiranih kadmijumom
Protective effect of selenium on antioxidant defense system in the blood of rats treated with cadmium
Authors:Ognjanović, Branka I.
Marković, Snežana D.
Žikić, Radoslav V.
Štajn, Andraš Š.
Petrović, Vojislav M.
Article (Published version)
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The effects of cadmium (Cd, 15 mg/kg/day) on the blood antioxidant defense system and the possible protective effects of selenium (Se, 7 μg/kg/day) were studied. Chronic Cd administration resulted in increased activities of copper, zinc superoxide dismutase (CuZn SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in red blood cells (RBC), as well as glutathione S-transferase (GST) activity and vitamin E (Vit E) concentration in the plasma. Se induced a significant increase in GSH-Px and GST activities, as well as concentrations of vitamin C and E. Thus, the mechanism by which Se decreases Cd toxicity in rats, seems to rely on the protection of the antioxidant defense system in blood, possibly by forming non-toxic cadmium selenide. The accumulation of Cd in RBC also decreased significantly upon co-exposure to Se. The obtained results show, that Cd exhibit toxic effects on the antioxidant defense system in the blood of rats and that Se demonstrates the protective effect against Cd toxicity.
Keywords:selenium; cadmium; antioxidant defense system; blood; rat
Source:Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 2006, 42, 3, 247-256