Motor effects of amphetamine in rats pretreated with either dizocilpine or phencyclidine
Article (Published version)
© 2003 Elsevier Science B.V.
MetadataShow full item record
The aim of the present study was to examine motor effects of amphetamine (AMPH) in rats pretreated with either dizocilpine (MK-801) or phencyclidine (PCP), and to estimate possible differences in these effects. Our results showed that AMPH increases the duration of motor effects of PCP, while it does not change motor effects of MK-801. These findings may reflect different mechanisms of action of MK-801 and PCP, as well as selective influence of AMPH on metabolism of these drugs.
Keywords:Phencyclidine; Dizocilpine; Amphetamine; Motor activity; Rat
Source:Behavioural Brain Research, 2003, 147, 1-2, 211-215
- Ministry of Science, Technology and Development of the Republic of Serbia (Contract #1641)
- Ministry of Science, Technology and Development of the Republic of Serbia (Contract #1704)