Receptori spregnuti sa G proteinima - Nobelova nagrada za Hemiju 2012.
The Nobel Prize in Chemistry 2012 for studies of G-protein coupled receptors
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Two American scientists Robert J. Lefkowitz and Brian K. Kobilka won the 2012 Nobel Prize in Chemistry. They were awarded 'for groundbreaking discoveries that reveal the inner workings of an important family of such receptors: G-protein-coupled receptors', said the academy in a statement, adding that the studies by Lefkowitz and Kobilka are crucial for understanding how G-protein-coupled receptors function. Fine-tuned communication between individual cells is a prerequisite for maintaining homeostasis within a living organism. Cells have the ability to process amounts of information conveyed to them by extracellular About a thousand genes code for such receptors, for example, for light, flavor, odor, adrenalin, dopamine and serotonin and about half of all medications achieve their effect through GPCRs. Unfortunately for a long time, it wasn’t possible to study the detailed structure of GPCRs because of the great difficulties in crystallizing them. This Nobel Prize continues the proud tradition of recognizing crystallographers who are among the most persistent and fearless of all scientists.
Source:Hemijski pregled, 2012, 53, 6, 142-147