Inhibicija intracelularne esterazne aktivnosti hlorpromazinom
Inhibition of intracellular esterases by chlorpromazine
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Chlorpromazine, an ant/psychotic drug, is found to inhibit intracellular esterase As intracellular target esterases we used alpha-naphthyl acetate esterase, naphtol AS-D chloroacetate esterase and alpha-naphthyl butyrate esterase in polymorphonuclear neutrophyls, hepatocytes and neuronal cells of mouse In vitro study showed that Chlorpromazine affects esterases of all these cell types whereby the degree of the enzyme inhibition was dependent on the incubation time and drug concentration The correlation of this inhibitory effect in all the cell types, has been demonstrated whereby the polymorphonuclear neutrophyls were proved to be the most sensetive to chlorptomazine effect.