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Increased platelet aggregability following an atherogenic diet in rabbits

dc.creatorVelkovski, Saško D.
dc.creatorMazić, Sanja
dc.creatorNešić, Dejan M.
dc.creatorIgrački, Iva
dc.creatorMilošević, Verica
dc.creatorStarčević, Vesna P.
dc.date.accessioned2015-08-28T10:26:51Z
dc.date.available2015-08-28T10:26:51Z
dc.date.issued2002sr
dc.date.issued2002
dc.identifier.issn0567-8315sr
dc.identifier.otherRad_konverzija_503sr
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/460
dc.description.abstractIn atherosclerosis researches different animal models are used but the most common is the rabbit, because of the easy development of atherosclerotic lesions. Atherosclerosis is a multicellular process and platelets play an important role in atherogenesis. Excessive plasma lipids stimulate platelet aggregability and thus atherosclerosis development. The effects of an atherogenic diet on lipid status, abdominal aorta wall structure, and platelet aggregability were studied in rabbits. Adult male Chinchilla rabbits were fed an atherogenic diet (2% edible oil solution of crystaline cholesterol at 8 mg cholesterol per kg b.wt.daily) for 8 weeks. Plasma lipid levels (triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol and LDL/HDL ratio) and platelet aggregability were then measured and compared to the values obtained for control animals. Histological analysis showed atherogenic changes in the abdominal aorta wall of the experimental animals. Total plasma cholesterol level, plasma LDL-cholesterol, and LDL/HDL ratio were significantly increased compared to the controls (p<0.01), as well as triglyceride and HDL-cholesterol levels (p <0.05). Platelet aggregability was also significantly increased (p<0.01) after the atherogenic diet in comparison with controls when ADP, at concentrations both of 5 and 10 (mol/L, was used as the aggregant. Disaggregation was common in control animals but this phenomenon was not recorded in the experimental animals. It can be concluded that an 8-week atherogenic diet in rabbits induced marked changes of the lipid parameters, provoked atherogenic changes in the abdominal aorta wall and increased platelet aggregability.en
dc.description.abstractU istraživanjima ateroskleroze korišćeni su razlčiti animalni modeli, ali najčešće korišćene životinje su kunići zbog toga što lako razvijaju aterosklerozne lezije. Ateroskleroza je multicelularni proces i trombociti igraju važnu ulogu u aterogenezi. Prekomerna koncentracija lipida u plazmi izaziva povećanu agregaciju trombocita i na taj način pospešuje razvoj ateroskleroze. Istraživali smo efekte aterogene dijete na lipidni status promene na" abdominalnoj aorti i agregabilnost trombocita u kunića. Odrasli mužjaci Cinčila kunića bill su podvrgnuti aterogenoj dijeti koja se sastojala od 2% rastvora kristalnog holesterola u jestivom ulju u toku 8 nedelja. Dnevna doza holesterola bila je 8 mg/kg telesne mase. Po završetku dijete, određivane su koncentracije triglicerida, ukupnog holesterola, LDL holesterola i HDL holesterola, odnos LDL/HDL, kao i agregabilnost trombocita. Vrednosti su poređene sa kontrolnim životinjama. Histološka analiza je pokazala aterogene promene u zidu abdominalne aorte eksperimentalnih životinja. Koncentracije ukupnog i LDL holesterola u plazmi kao i odnos LDL/HDL bili su visoko statisticki značajno povećane (p<0,01). Koncentracije triglicerida i HDL-holesterola u plazmi takođe su bile statističk značajno povećane (p<0,05). Agregabilnost trombocita bila je statisticki visoko značajno povećana (p<0,01) posle aterogene dijete, bez obzira na to da II je agregant ADP korišćen u koncentraciji 5 ili 10 (mol/L. Fenomen dezagregacije bio je uobičajen za kontrolne životinje, ali nije registrovan kod eksperimentalnih životinja. Može se zaključiti da je osmonedeljna aterogena dijeta u kunića izazvala značajne promene lipidnih varijabli, izazvala nastanak aterogenih promena u zidu abdominalne aorte i povećala agregabilnost trombocita.sr
dc.description.sponsorshipnullsr
dc.language.isoengsr
dc.rightsopenAccesssr
dc.sourceActa veterinariasr
dc.subjecthyperlipoproteinemiaENG
dc.subjectplatelet aggregationENG
dc.subjectatherosclerosisENG
dc.subjectrabbitsENG
dc.titlePovećana agregabilnost trombocita posle aterogene dijete u kunićasr
dc.titleIncreased platelet aggregability following an atherogenic diet in rabbitsen
dc.typearticlesr
dc.rights.licenseARR
dcterms.abstractИграчки, Ива; Велковски, Сашко Д.; Мазић, Сања; Нешић, Дејан М.; Милошевић, Верица Л.; Старчевић, Весна П.; Повећана агрегабилност тромбоцита после атерогене дијете у кунића; Повећана агрегабилност тромбоцита после атерогене дијете у кунића;
dc.citation.issue1sr
dc.citation.volume52sr
dc.citation.spage11sr
dc.citation.epage18sr
dc.type.versionpublishedVersionsr
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs//bitstream/id/2842/Rad_konverzija_503.pdf
dc.citation.rankM23


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