The effect of selenium on antioxidant defense system in the blood of rats chronically treated with cadmium
Ognjanović, Branka I.
Žikić, Radoslav V.
Štajn, Andraš Š.
Petrović, Vojislav M.
Article (Published version)
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The effect of selenium (Se, 7 µg/kg/day, during 30 days) on the antioxidant defense system (AOS): copper zinc containing superoxide dismutase (CuZn SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities in red blood cells (RBC) and glutathione-S-transferase (GST) activity in the plasma, as well as ascorbic acid (AsA) and vitamin E (Vit E) concentrations in the plasma of rats chronically treated with cadmium (Cd, 15 mg/kg/day, during 30 days) was analyzed. All results of experimental groups were compared with control animals. Cd led to increased the activities of CuZn SOD, CAT and GSH-Px, as well as GST activity and Vit E concentration. Se induced a significant increase in GSH-Px and GST activities, as well as concentrations of AsA and Vit E. In animals exposed both to Cd and Se a significant increase of GSH-Px activity was observed. The accumulation of Cd was significantly increased in the plasma of Cd+Se treated and in RBC of Cd treated animals, while it was markedly lower in RBC of Cd+Se treated rats. The obtained results show, that Cd exhibit toxic effects on the antioxidant defense system in the blood of rats and that Se demonstrates protective role against Cd toxicity.
Source:Kragujevac Journal of Science, 2001, null, 23, 105-114