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Effects of depkenyl, resekpine and their combination on the antioxidant enzyme activities in the rat brain

dc.creatorBožić, Ivana
dc.creatorNikolić, Aleksandra
dc.creatorSaičić, Zorica
dc.creatorMiljević, Č.D.
dc.creatorSpasić, Mihajlo
dc.creatorPetrović, V.M.
dc.date.accessioned2015-08-28T10:26:51Z
dc.date.available2015-08-28T10:26:51Z
dc.date.issued2000sr
dc.date.issued2000
dc.identifier.issn0354-4664sr
dc.identifier.otherRad_konverzija_133sr
dc.identifier.urihttps://ibiss-r.rcub.bg.ac.rs/handle/123456789/49
dc.description.abstractAntioxidant enzyme activities: superoxide dismutases (CuZn SOD and Mn SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) and glutathione reductase (GR) were determined in different brain regions: striatum, hippocampus, hypothalamus with thalamus, as well as in the rest of the brain of rats treated subchronically with L-deprenyl, after a single dose of reserpine and in animals subchronically treated with L-deprenyl and then with reserpine. Our results show that reserpine (p < 0.02), as well as, the combination of deprenyl + reserpine (p<0.01) induced a significant decrease in CAT activity in the rest of the brain and a significant decrease in GSH-Px activity in the hypothalamus with thalamus (p<0.05). Deprenyl expressed no significant effect on antioxidant enzyme activities in the examined brain regions. In experimental group treated with deprenyl and then with reserpine a significant decrease of CuZn SOD activity (p<0.05) in the hippocampus, Mn SOD activity (p<0.05) in the striatum and an increase of CnZn SOD activity (p<0.01) in the rest of the brain were observed. Our results support the opinion that depletion of neuronal catecholamine pool (due to the treatment with reserpine) has a direct influence on antioxidant enzyme activities, while deprenyl probably exerts its effects through interaction with some trophic factors.en
dc.description.abstractAktivnost antioksidativnih enzima: superoksid dismutaze (CuZn SOD i Mn SOD), katalaze (CAT), glutation peroksidaze (GSH-Px), glutation-S-trans-feraze (GST) i glutation reduktaze (GR) u strijatumu, hipokampusu, hipotalamusu sa talamusom, kao i ostatku mozga, praćena je u eksperimentima subhroničnog tretiranja pacova L-deprenilom, akutnog rezerpinom i u kombinaciji oba. Naši rezultati pokazuju da rezerpin (r<0.02), kao i kombinacija deprenila i rezeršša (r<0.01) dovode do smanjenja aktivnosti CAT u ostatku mozga i aktivnosti GSH-Px (r< 0.05) u hipotalamusu sa talamusom. Deprenil ne izaziva značajne promene enzimske aktivnosti u ispitivanim regionima mozga. U eksperimentalnoj grupi tretiranoj deprenilom, pa rezerpinom dolazi do značajnog smanjenja aktivnosti CuZn SOD (p< 0.005) hipokampusa, aktivnosti Mn SOD strijatuma (p<0i)5) i povećnja aktivnosti CuZn SOD (r<0.01) ostatka mozga. Ovi rezultati ukazuju da iscriljenje pula kateholamina (usled tretmana rezerpinom) ima direktan uticaj na aktivnost antioksidativnih enzima, dok su za efekte deprenila značajne interakcije sa nekim trofičkim faktorima.sr
dc.description.sponsorshipnullsr
dc.language.isoengsr
dc.rightsopenAccesssr
dc.sourceArchives of Biological Sciencessr
dc.titleEfekti deprenila, rezerpina i njihove kombinacije na aktivnost antioksidativnih enzima u mozgu pacovasr
dc.titleEffects of depkenyl, resekpine and their combination on the antioxidant enzyme activities in the rat brainen
dc.typearticlesr
dc.rights.licenseARR
dcterms.abstractСпасић, М.Б.; Николић, Aлександра; Божић, Ивана; Петровић, В.М.; Саичић, Зорица; Миљевић, Ч.Д.; Ефекти депренила, резерпина и њихове комбинације на активност антиоксидативних ензима у мозгу пацова; Ефекти депренила, резерпина и њихове комбинације на активност антиоксидативних ензима у мозгу пацова;
dc.citation.issue1sr
dc.citation.volume52sr
dc.citation.spage21sr
dc.citation.epage26sr
dc.type.versionpublishedVersionsr
dc.identifier.fulltexthttp://ibiss-r.rcub.bg.ac.rs//bitstream/id/2778/Rad_konverzija_133.pdf


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