Moguća uloga metalotioneina i proteina toplotnog stresa u zaštiti glukokokortikoidnog receptora u uslovima trovanja kadmijumom
A possible role of metallothionein and heat shock proteins in glucocorticoid receptor protection against cadmium intoxication
Authors:Dunđerski, Jadranka S.
Article (Published version)
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The participation of metallothionein (Mt) and heat shock proteins (Hsps) in protection of glucocorticoid receptor (GR) binding capacity from a toxic metal cadmium (Cd), was investigated. Specific binding of a glucocorticoid to GR in the rat liver cytosol was studied after in vitro and in vivo Cd treatment. Reduction of the GR binding capacity observed after in vitro treatment was proportional to the applied metal concentrations. In animals administered different Cd doses, GR binding capacity was not reduced, except in those that received the highest dose, and a concomitant elevation of Mt, Hsp70 and Hsp90 levels was detected. The results led to the assumption that Cd-induced reduction of the GR binding capacity noticed in vitro, was prevented in intact animals by the elevated levels of Mt and Hsps.